Another study demonstrated that calcitriol decreased the cell growth of tamoxifen-sensitive and -resistant BC cells by inhibiting the NFκβ pathway through increased gene expression of NFκβ inhibiting protein IκB, with a concomitant reduction of tumor necrosis factor alpha (TNFα)-induced p65 phosphorylation, as well as its translocation into the nucleus [160]. The gene discussed is TNF; the disease is breast cancer.