Although direct activation of N-Myc by E2F1 is yet to be demonstrated in PCa and further studies are needed, E2Fs have been reported to promote N-Myc expression by binding to MYCN promoter in other cancer types [68], raising the possibility that N-Myc elevation, triggered by dysregulated E2F1 cistrome, may contribute to NE/SC development. Here, MYCN is linked to cancer.