Recently, Labrecque et al. proposed classifying disease continuum between CRPC adenocarcinoma and NE/SC into the following five categories: ARPC (adenocarcinomas with AR and PSA), AR-low PCa (weak AR and PSA, and negative for NE markers), amphicrine PCa (coexpress AR, PSA, and NE markers), double-negative PCa (DNPC, negative for AR, PSA, and NE markers) and NE/SC [65]. This evidence concerns the gene AR and posterior cortical atrophy.