GBA1 and Parkinson disease: To assess the neuroprotective effects of glitazones in our GBA deficiency fly model of PD, we used the sleep deficit phenotype to screen for potential neuroprotective effects of the glitazone drugs troglitazone (TGZ) and pioglitazone (PGZ) at three different doses: 500 nM, 1 μM, and 2 μM.