Although the analysis identified several hundred DMRs between these groups by pairwise comparisons, after correction for multiple testing only DMRs of three genes (CLDN16, DDC, NXT2) showed statistically significant differences between pre-symptomatic HD patients and controls, and there were no significant differences in other comparisons (controls vs. symptomatic patients, pre-symptomatic vs. symptomatic patients, controls vs. all HD patients). The gene discussed is NXT2; the disease is Huntington disease.