As polarity impairment is a common event in human cancers, and occurs as an early event in cancer development [98,99,100,101], understanding the role that PTP1B and TCPTP play in the regulation of signalling pathways in polarity-impaired cancer models may provide new ways by which to target cancers at an early stage to enhance cell competition mechanisms and tumor suppressor functions. This evidence concerns the gene PTPN1 and cancer.