PTPN2 and neoplasm: As polarity impairment is a common event in human cancers, and occurs as an early event in cancer development [98,99,100,101], understanding the role that PTP1B and TCPTP play in the regulation of signalling pathways in polarity-impaired cancer models may provide new ways by which to target cancers at an early stage to enhance cell competition mechanisms and tumor suppressor functions.