For instance, a hemizygous de novo 2.8-Mb microdeletion Xp22.2–Xp22.13 was described, including the CDKL5 and NHS genes, both contributing to the associated phenotypic presentation of severe encephalopathy, congenital cataracts, and tetralogy of Fallot in a 10-month-old boy [41]. Here, CDKL5 is linked to early-onset non-syndromic cataract.