RAI2 and Nance-Horan syndrome: On Xp22.13, SCLM1 is likely involved in spermatogenesis, with a potential role in azoospermia [40], SCLM2 seem to participate in embryonic development and RAI2 is a retinoic acid-induced gene that may play a role in cardiogenesis, for which a potential implication on cardiac anomalies in Nance-Horan syndrome has been previously speculated [23,33,39,40,41].