T cell defects, T cell lymphomas, and increased incidence of CD3+, CD4+, CD8+, CD3+HLA-DR+, CD4+HLA-DR+, and CD8+HLA-DR+ subset of activated T cells have been observed in lung and peripheral blood of patients with GD [41,42,43,44,45,46]. This evidence concerns the gene CD8A and T-cell non-Hodgkin lymphoma.