Utilizing multi-omic functional genomics data associated with glioma phenotypes showed that GRPEL2 mRNA expression was exclusively correlated with oligodendroglial differentiation in the phenotypes of oligodendroglioma (O), anaplastic oligodendroglioma (AO), and GBM in all datasets (p < 0.05, Figure 2A). This evidence concerns the gene GRPEL2 and central nervous system cancer.