Poillet et al. proposed an important therapeutic approach to kill cancer cells by ROS-induced senescence dependent on the inactivation of autophagy-related gene-4 (ATG4), increasing LC3-associated autophagosomes and the ATM-mediated oxidation of AMP-activated protein kinase (AMPK), and inhibiting mTORC1 [51]. The gene discussed is ATM; the disease is cancer.