GRPEL2 and glioblastoma: We used the flow cytometry to detect the senescence and autophagy of GBM cells treated with siGRPEL2 at 25 μM, and the results showed that the inhibition of GRPEL2 enhanced the senescent expression (p < 0.01, Figure 8A,B) and autophagic flux (p < 0.01, Figure 8C,D).