Further immunostaining confirmed that an elevated GRPEL2 staining (by immunoscore) significantly correlated with the WHO tumor grade (p < 0.05, Figure 3B) and that a greater GRPEL2 staining (by immunoscore) was associated with higher-grade gliomas (WHO 3 to 4, p < 0.05, Figure 3C). The gene discussed is GRPEL2; the disease is central nervous system cancer.