IDH3A and anaplastic astrocytoma: Isocitrate dehydrogenases (IDHs) are a group of enzymes that play a crucial role in the TCA cycle by catalyzing the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG) and linking to the prognosis amongst anaplastic astrocytoma, GBM [2], and other forms of malignancy-associated metabolic reprogramming [23,25].