We first examined by ELISA the concentrations of PLA1A in platelet-free plasma from 12 healthy donors, 38 early-diagnosed arthritis (EA) patients, and 62 SLE patients undergoing treatment as well as in hyaluronidase-treated synovial fluids from five RA patients, three psoriatic arthritis (PsoA) patients, three osteoarthritis (OA) patients, and three gout patients. The gene discussed is PLA1A; the disease is osteoarthritis.