Further, we analyzed the sequences of the BTK, PI3K, and PTEN genes for SNVs and compared them across several canine B-, T-lymphoid cell lines and a set of canine primary B-cell lymphoma samples searching for potentially high-impact variants in the genes that encode the primary targets of ibrutinib and AS-605240. The gene discussed is PIK3CD; the disease is B-cell non-Hodgkin lymphoma.