CREB1 and Nephropathy: Similar results were obtained after treatment with Umb in other models of kidney damage, with methotrexate that led to the reduction of apoptosis of kidney cells [64], and in another model of kidney damage with cisplatin, where an increase in the expression of genes such as CREB, SIRT1, FOXO-3, PPAR-γ, and NRF2 was associated with protection against nephrotoxicity [64].