CRB1 and Leber congenital amaurosis: Prior to this, CRB1 had only been associated with EORD (where it was responsible for 10 to 13% of LCA cases) or RP (responsible for 8% of cases) with specific clinical features, such as para-arteriolar preservation of the retinal pigment epithelium, peripheral nummular pigmentation or Coats-like disease [8,9,10,11,12,13,14,15,16].