Akkermansia muciniphila is mucin-degrading bacteria enriched in neurodegenerative diseases (such as Alzheimer’s disease or multiple sclerosis) and contributes to the progression of neural pathologies by degrading mucin increasing gut inflammation and permeability, and finally leading to higher endotoxemia and systemic inflammation [46,47]. The gene discussed is MUC5AC; the disease is early-onset autosomal dominant Alzheimer disease.