Additionally, an underrecognized entity termed cholemic nephropathy has been described [31] in patients with cirrhosis and elevated bilirubin, with studies suggesting a decreased expression of aquaporin-2-receptors in patients with elevated bilirubin [32] and some studies have demonstrated that patients with elevated bilirubin and HRS-AKI have less response to terlipressin and albumin [14], suggesting a possible pathophysiologic contribution of elevated bilirubin in the development of HRS. The gene discussed is ALB; the disease is Cirrhosis.