GPT and hepatitis A virus infection: We also chose the practical cutoffs of HBsAg and HBeAg in predicting significant hepatitis activity in a subpopulation with possible high HBV replication and of HBV DNA and HBeAg in predicting significant hepatitis activity in a subpopulation with possible low HBV replication, and evaluated the reliability of HBsAg, HBeAg or HBV DNA alone and in combination with ALT in predicting liver pathological grades and stages.