We also chose the practical cutoffs of HBsAg and HBeAg in predicting significant hepatitis activity in a subpopulation with possible high HBV replication and of HBV DNA and HBeAg in predicting significant hepatitis activity in a subpopulation with possible low HBV replication, and evaluated the reliability of HBsAg, HBeAg or HBV DNA alone and in combination with ALT in predicting liver pathological grades and stages. Here, GPT is linked to Hepatitis.