These suggested that the ability of ALT based on the three preset ULNs and of HBV DNA with reference to the practical cutoff alone and in combination with ALT for excluding extensive liver fibrosis and cirrhosis is all very limited; however, the performances of HBsAg with the standard of the practical cutoff alone and in combination with ALT for excluding extensive liver fibrosis and cirrhosis are both almost excellent. This evidence concerns the gene GPT and Cirrhosis.