The ROC curve analyses of this study showed that, in the overall population, the AUCs of HBsAg, HBeAg and HBV DNA for predicting significant hepatitis activity were all less than 0.70; among them, the AUCs of HBsAg for predicting “ALT ≥ ULNs or Grade > G1 or Stage > S1” were all greater and all less than those of HBV DNA. This evidence concerns the gene GPT and hepatitis A virus infection.