In the subpopulation with possible high HBV replication, HBsAg and HBeAg instead of HBV DNA were significantly negatively correlated with ALT, and had very good and good performance in predicting “biochemical or pathological” significant hepatitis activity; in the subpopulation with possible low HBV replication, HBV DNA and HBeAg instead of HBsAg were significantly positively correlated with ALT, and had very good and good performance in predicting biochemically significant hepatitis activity. Here, GPT is linked to Hepatitis.