GPT and Hepatic fibrosis: In HBeAg-positive patients, HBsAg levels in the non-significant hepatitis activity phase were significantly higher than those in the significant hepatitis activity phase [13,14], and HBsAg showed good performance in predicting significant hepatitis activity, significant liver fibrosis with ALT less than 2 × ULN and liver cirrhosis without considering ALT levels [15,16,17].