In contrast, for instance, in the recent study from Belarus, it was reported that as many as 18 patients were treated with drugs known to be ineffective in HAE: antihistamines, corticosteroids, tranexamic acid and only nine patients were given adequate treatment (icatibant, i.v. C1-INH concentrate or infusion of fresh frozen plasma) [12]. Here, SERPING1 is linked to hereditary angioedema.