According to that, an increased ACE/ACE2 activity ratio generated by the downregulation action of SARS-CoV2 on ACE2 [18,22,23,24] will lead to increased Angiotensin II [18] and increased catabolism of Angiotensin 1–7, towards vasoconstriction, endothelial dysfunction, prothrombosis, proinflammatory, and antinatriuretic effect [19,22]. Here, ACE2 is linked to endothelial dysfunction.