To date, downregulation of alpha-catenin, which is an intracellular element of e-cadherin, has been suggested as a predictor of unfavorable outcome including baseline grading [31] and staging [31,32,33], positive surgical margins [33], BCR [34], as well as cancer-specific survival in organ-confined [34], locally-advanced [35], and metastatic [32] patients. This evidence concerns the gene CDH1 and cancer.