Recently, VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic), a newly established X-linked disease associated with a somatic mutation in a gene encoding ubiquitin-like modifier activating enzyme 1 (UBA1) characterized by lipid vacuole inclusions in myeloid precursors of bone marrow examination, has been described [18]. The gene discussed is UBA1; the disease is X-linked disease.