Regarding CRC, MCP-2/CCL8 derived from cancer-associated fibroblasts have been shown to stimulate the proliferation of cancer cells [31], while MCP-2/CCL8 and MCP-3/CCL7 derived from tumor-associated macrophages attract anti-tumor CD4+ and CD8+ T cells [44]. The gene discussed is CD4; the disease is colorectal carcinoma.