CCL8 and osteosarcoma: In osteosarcoma [38] and melanoma [39], high CCL8 expression has been a good prognosticator and correlated with tumor infiltration with CD8+ T cells and M1 macrophages [38], while in animal models, MCP-2/CCL8 negatively affected the proliferation of melanoma cells and reduced the number of liver metastases [40].