TNFSF10 and cancer: Okubo et al. explored the new approach to the cancer treatment by the induction of the endoplasmic reticulum: Lopinavir/Ritonavir inhibited synergistically the growth of BCa cells through the induction of stress in the endoplasmic reticulum with: increased expression of the AMP-activated protein kinase, suppression of the mammalian target of rapamycin pathway, increased expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and a sensitization of neoplastic cells to TRAIL [4].