Whilst variants affecting the related FXR1 gene confer risk to schizophrenia, bipolar disorder, and autism [161, 162, 163, 164, 165], the genetic link between FMR1 and psychiatric disorders derives from enrichment of association within the gene targets of FMRP (among which the fragile-X family genes themselves are included). Here, FMR1 is linked to bipolar disorder.