Their anti‐cancer effects are associated with disrupting the cell cycle via the induction of arrest at G2/M phase (Eun & Woong, 2008), down‐regulation of cell migration proteins expression, such as EGFR, matrix metalloproteinase 2 (MMP‐2), MMP‐9, and vascular endothelial growth factor, inducing autophagy by inactivating the Akt‐mTOR pathway (Balakrishnan et al., 2016; Jia et al., 2018), and inducing apoptosis via p53 phosphorylation in human breast carcinoma cells (Eun & Woong, 2008). This evidence concerns the gene MMP2 and breast carcinoma.