Mur et al. (2018) sequenced Bub3 in 456 familial CRC cases and in 88 polyposis cases and found Bub3 c.77C>T (p.T26I) in patient diagnosed with prostate cancer at age 70 and 2 cases of synchronous CRC and 22 cases of adenomatous polyps at age 73. Here, BUB3 is linked to polyposis.