In an non‐small cell lung cancer (NSCLC) study, Guo et al. (2021) found that the overexpression of lnc CRYBG3 RNA inhibited the interaction between Cdc20 and Bub3, which activated the APC/C complex prematurely, causing aneuploidy and accelerated development of NSCLC. The gene discussed is BUB3; the disease is lung cancer.