We investigated the stability and conformational space of the RG‐1 RNA‐G‐quadruplex of the SARS‐CoV‐2 N‐gene in the presence of salts, cosolutes, crowders and intrinsically disordered peptides, focusing on α‐Synuclein and the human islet amyloid polypeptide, which are involved in Parkinson's disease (PD) and type‐II diabetes mellitus (T2DM), respectively. This evidence concerns the gene IAPP and type 2 diabetes mellitus.