Moreover, we speculate that as patients with high-risk preeclampsia with increased sFlt-1/PlGF ratio suffer more severe systemic endothelial dysfunction and vasoconstriction than low-risk patients, these systemic endothelial and vascular changes lead to suppression of angiogenesis or vascular permeability in the choroidal tissue. The gene discussed is PGF; the disease is endothelial dysfunction.