Lendvai et al. [41] used Methylated DNA Immunoprecipitation (MeDIP) combined with DNA microarray to identify two differentially methylated regions of COL25A1 and KATNAL2 genes as having significantly progressive methylation with increasing severity of CIN compared with normal cervical epithelium. This evidence concerns the gene COL25A1 and cervical squamous intraepithelial neoplasia.