In HLA Class I, the HLA-A*26:02 (2.5% vs. 10.6% p = 0.030, OR 0.22 CI 0.05–0.98) and HLA-C*08:01 (5.0% vs.15.5% p = 0.020, OR 0.29 CI 0.10–0.87) allele frequencies were significantly lower in the GBM group (Table 2). This evidence concerns the gene HLA-C and glioblastoma.