Table 2 shows the independent predictors for developing HCC adjusted for age, sex, race, DM duration, weight loss, loss of appetite, abdominal pain/discomfort, viral hepatitis, non-alcoholic fatty liver, metformin, gliclazide, insulin, statins, blood transfusion, alcohol, smoking, traditional medication, HbA1c, WBC, RBC, platelet count, AGR, total bilirubin, ALP, ALT, INR, and creatinine. This evidence concerns the gene INS and hepatocellular carcinoma.