We first examined genes that may render cell-growth advantage through analysis of our CRISPR/Cas9 perturbation screen in JeKo-1 cells and found that many critical tumor suppressors were located on chr9, including CDKN2A, SMARCA2, FBXO10, and TOR1B (Figure 4A; z score ≥ 1). Here, CDKN2A is linked to neoplasm.