AICDA and leukemia: This includes an age-related signature involving C-to-T transitions at CpG sites; a c-AID signature characterized by increased C>T/G mutations at a known activation-induced cytidine deaminase (AID) hotspot (SBS84); an enzyme essential for somatic hypermutation of germinal center B cells; and signatures 5 and 40, common signatures that were prevalent in most cancers and leukemia/lymphoma, respectively.