Silencing of SP140, SMARCA4, PCLO, TP53, and TRAF2 in JeKo-1 cells conferred a cell-growth advantage, while knockdown of these genes in other cell lines had modest or no impact on cell growth (Figure 1D and Supplemental Figure 3C), indicating that these genes may act as tumor suppressors in MCL. This evidence concerns the gene PCLO and mantle cell lymphoma.