TLR3 and central nervous system neoplasm: We have previously reported that coadministration of a TLR3 ligand, polyinosinic-polycytidylic acid (poly-IC) stabilized with poly-lysine and carboxymethylcellulose (poly-ICLC), enhanced CNS tumor-trafficking of vaccine-induced effector T cells, resulting in a therapeutic effect in rodent CNS tumor models in a CXCL10-dependent manner (14).