In brief, the nano-cascaded enzymes Ti3C2-GOX-CPO/TPZ (TGCT) were prepared by conjugating GOX and CPO onto the Ti3C2 2D nanosheets with TPZ drug loading, then CD47-overexpressed cancer cell membrane biomimetic modification was utilized to form a bionic cascaded-enzyme nanoreactor (denoted as meTGCT). This evidence concerns the gene CPO and cancer.