Concerning pathophysiology, increased concentrations of CRP might be induced by the autocrine secretion of interleukin-6 in neoplastic Schwann cells, and CRP promotes the differentiation of monocytes toward proinflammatory M1 macrophages, which are predominant in VS tissue and drive the growth of the tumor through paracrine communication between Schwann cells and TAMs. Here, IL6 is linked to neoplasm.