Notably, patients (p = 0.0001) and L2-IL1b mice showed a statistically significant increase in the Hsp70 expression during stepwise progression from non-dysplastic BE to LGD to high-grade dysplasia (HGD) and EAC (Fig. 1, C and D), suggesting that Hsp70 expression correlates closely with disease progression. This evidence concerns the gene IL1B and Barrett esophagus.