Also, systemic administration of a single adenoviral vector encoding pdx1, MafA, and ngn3 factors reprogrammed duct-like SOX9-positive cells in the liver into insulin-producing cells and improved hyperglycemia in non-obese diabetic/severe combined immunodeficient (NOD/SCID) mice treated with streptozotocin [47]. The gene discussed is MAFA; the disease is Hyperglycemia.