Whereas TOX and PD-1 expression were reduced at this dose of FK506, other transcription factors altered by Preg-TEX cells and TEX cells in cancer and chronic infection compared with canonical memory T cells (i.e., Aiolos [Ikzf3], SATB1) were less impacted by FK506 treatment, indicating a selective effect on some but not all pathways of T cell differentiation (Fig. 8 E). This evidence concerns the gene IKZF3 and cancer.