We also found a very small but significant difference in the oxygen consumption levels exhibited by Lpp-WT- and Lpp Δspl-infected hMDMs (p=0.0148, Figure 2—figure supplement 1A), suggesting that the role of LpSpl in the induction of the ‘reverse mode’ to maintain Δψm during infection might partially involve the modulation of the functioning of the OXPHOS machinery. Here, LPP is linked to infection.