POMC and Cushing syndrome due to macronodular adrenal hyperplasia: For both the ACTH stimulation test and the LDDST, specificity estimates not highly accurate indicating that some falsely diagnosed cases of Cushing's syndrome were likely included in the present study (Van Liew et al. 1997, Monroe et al. 2012, Bennaim et al. 2018, Nivy et al. 2018).