No diagnostic tests currently available for the diagnosis of Cushing's syndrome are highly accurate, however, alternative tests such as the LDDST and dynamic tests based on measuring UCCR are more sensitive than the ACTH stimulation test (Feldman 1983, Rijnberk & Mol 1988, Galac et al. 1997, Bennaim et al. 2018). This evidence concerns the gene POMC and Cushing syndrome due to macronodular adrenal hyperplasia.