Vizcarra et al. [112] validated previously published ML algorithms using convolutional neural networks (CNNs) and to determine if pathological heterogeneity may alter algorithm-derived measures using 40 cases from the Goizueta Emory Alzheimer's Disease Center brain bank, which displays an array of pathological diagnoses (including AD with and without Lewy body disease (LBD) and/or TDP-43-positive inclusions) and evaluated their levels of Aβ pathologies. Here, TARDBP is linked to Alzheimer disease.