PLK1 and colorectal carcinoma: A functional study showed that depletion of PLK1 by two individual small interfering RNAs (siRNAs) significantly inhibited the proliferation and colony formation of CRC cells (Figure 1E,F), which was further confirmed by using two PLK1 inhibitors (GSK461364 and volasertib) (Figure 1G,H; Figure S1G,H, Supporting Information).