PLK1 and cancer: In addition, GSEA showed that MYC target genes were remarkably suppressed by PLK1 inhibition (Figure S4A,C, Supporting Information), which is consistent with previous studies that showed that PLK1 confers oncogenic transformation by stabilizing MYC activation.[14, 28, 29] To determine whether these downstream targets were directly regulated by MYC transactivation, we examined the MYC ChIP‐seq database in various cancer cells.