In carcinoma‐associated thrombocytosis, it is hypothesized that tumor production of IL‐6 directly leads to the generation of hepatic thrombopoietin (TPO), which stimulates megakaryocytic generation of platelets.20, 22, 23, 24, 25, 26, 27, 28, 29. The gene discussed is THPO; the disease is thrombocytosis disease.