The most recent extensive correlative analysis on large numbers of neurodegenerative disease patients however indicates that NF-L does not appear to be a highly selective biomarker for any single neurodegenerative diseases or for AD at any stage, but rather an indicator for dendritic damage, axonal deterioration, overall neural cell demise, neurite regression and synaptic atrophy, especially in progressive pathological disorders where large neurons and myelinated axons are involved [47,68,87]. The gene discussed is NEFL; the disease is Alzheimer disease.