NEFL and Alzheimer disease: When axonal and dendritic damage, inflammatory, neurodegenerative, traumatic or vascular injury occurs in multiple neurological disorders such as AD, ALS, PrD, VaD there often appear to be increases in NF-L accumulation in the CSF which are directly proportional to the severity of these progressive age-related neurodegenerative disorders [4,12,24,38,49,56,77].