Pathologically, NF-L filaments are further found within and/or associated with abnormal assemblies and disease-related accumulations and senile plaque lesions associated with amyloid beta (Aβ) peptide deposits in AD and synuclein in PD; NF-L proteins have also been found to directly associate with superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP43), neuronal RNA-binding FUS proteins, optineurin (OPTN), ubiquilin 2 (UBQLN2), dipeptide repeat protein (DRP), and synapsins and other pre-synaptic phosphoproteins [4,5,10,12,14,27,30,33,40,53,56,76]. The gene discussed is OPTN; the disease is Alzheimer disease.