The stoichiometry of these 3 NF subunits varies slightly, but is approximately 5:3:1 for NF-L:NF-M:NF-H in large neurons of the human brain neocortex; large neocortical layer 3 and 5 pyramidal neurons of the neocortex are specifically targeted and devastated by the Alzheimer’s disease (AD) process [1–4]. The gene discussed is NEFL; the disease is early-onset autosomal dominant Alzheimer disease.