An augmentation or interference of axonal IF trafficking by disorganized or modified NFs, and deficits or alterations in NF transport or translocation across the neuronal plasma or cytoplasmic membranes has been proposed as one possible mechanism of NF-mediated neuropathology in both AD and ALS and perhaps other neurological disorders [5,39,60–65]. This evidence concerns the gene NFASC and nervous system disorder.