Again both NF-L and SYN-II expression are observed to be down-regulated in multiple neuropsychiatric disorders involving progressive axonal and neuronal atrophy and neurodegeneration [11,30,36,37,39,48] Largely because of the high stability and long half-life of NF-L compared to SYN-II the major focus of this short review will be on NF-L and its translocation from a highly polymerized structural component of the neuronal cytoskeleton to a neurodegenerative disease biomarker in multiple biofluids of the periphery. The gene discussed is SYN2; the disease is neurodegenerative disease.