Primary MR analyses revealed an inverse causal effect of IL-6 on HF risk (OR = 0.86, 95% CI 0.81–0.91, p < 0.001), whereas no significant association between genetically determined IL-1β (OR = 1.04, 95% CI 0.86–1.25, p = 0.70), IL-1ra (OR = 0.95, 95% CI 0.83–1.10, p = 0.51), and sIL-6r (OR = 0.96, 95% CI 0.91–1.01, p = 0.14) with HF development was observed (Table 2). Here, IL1B is linked to hydrops fetalis.