Twenty caffeine-involved signaling pathways were related to NASH, such as chemokine signaling, cytokine-cytokine receptor interaction, phagosome, ECM-receptor interaction, PI3K-AKT signaling, MAPK signaling, Toll-like receptor signaling, NOD-like receptor signaling, and NF-κB signaling. This evidence concerns the gene AKT1 and metabolic dysfunction-associated steatohepatitis.