Epidemiological and clinical investigations have suggested that the consumption of coffee could reduce the risk of alcoholic liver cirrhosis (15), type-2 diabetes (16), NAFLD (17), and HCC (18, 19), and reduce the progression of NASH, the severity of fibrosis (20), and alanine aminotransferase (ALT) activity in patients with liver injury (21). This evidence concerns the gene GPT and hepatocellular carcinoma.