The studies on the predictive risk factors for RP-ILD in the patients with anti-MDA5+ DM revealed that biomarker, such as ferritin, Krebs von den Lungen-6 (KL-6), MDA5 antibody titers, and baseline forced vital capacity (FVC) were considered to be important in evaluating the disease activity and prognosis (8, 9). This evidence concerns the gene IFIH1 and interstitial lung disease.