INS and hypertensive disorder: Moreover, improved hypertension in the majority of our study sample not only has the unilateral impact of improving cardiovascular and cerebrovascular-related morbidity, but it induces physiologic changes such as reductions in insulin resistance, enhanced sodium retention, and changes in natriuretic peptide, that enhances weight loss compared to patients who are seeking weight control with uncontrolled hypertension status (60–71).