Hsa_circ_0067934 (Xin et al., 2019), circ-EPB41L5 (Lv et al., 2020) and circ-ABCC3(Zhang and Xu, 2021) can participate in the invasion and metastasis of GBM by regulating the PI3K/Akt/mtor signaling pathway. Here, AKT1 is linked to glioblastoma.