Interventions using elF5A inhibition with GC7 of CD4 T cell subsets (T helper and Treg) resulted in amelioration of T1D but was not able to revert T1D, at least in our humanized T1D mouse model until interventions like anti-DLL4 restrained autoreactive CTLs in the islet microenvironment. This evidence concerns the gene DLL4 and type 1 diabetes mellitus.