Recently, tumor suppressive circPSMC3, down-regulated in ESCC tissues and gefitinib-resistant (GR) ESCC cells, its overexpression could conquer gefitinib resistance, increase apoptosis rate and cleaved caspase-3 level in GR ESCC cells through modulating the miR-10a-5p/PTEN axis, which provide a promising therapeutic strategy for overcoming gefitinib resistance in ESCC (Zhu H. et al., 2021). Here, PTEN is linked to esophageal squamous cell carcinoma.