C3 and neoplasm: In human tumors, six types of immune infiltrate were established that ranges from tumor-promotion to tumor-suppression (Tamborero et al., 2018), including C1 (wound healing), C2 (INF-γ dominant), C3 (inflammatory), C4 (lymphocyte depleted), C5 (immunologically quiet), and C6 (TGF-β dominant).